Best Cold And Sinus Medicine in 2025
Updated on April 2025
#1
Recommended
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- Contains 20 coated tablets for sinus congestion and pain relief.
- 200mg ibuprofen for temporary relief of fever and minor aches.
- 10mg phenylephrine HCl for relief from sinus pressure and nasal congestion.
- Portable coated tablets for convenience.
- Suitable for adults and children 12 and older.
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- Contains 20 coated tablets for sinus congestion and pain relief.
- 200mg ibuprofen for temporary relief of fever and minor aches.
- 10mg phenylephrine HCl for relief from sinus pressure and nasal congestion.
- Portable coated tablets for convenience.
- Suitable for adults and children 12 and older.
#2
Value for Money
22% Off
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- Relieves severe congestion and pain, including headaches and nasal congestion.
- Trusted cold and cough brand among healthcare professionals.
- Contains Acetaminophen for effective relief of minor aches and pains.
- Includes Guaifenesin to thin and loosen mucus for chest congestion relief.
- Features Phenylephrine HCl to alleviate nasal and sinus congestion and pressure.
- Intended for users aged 12 years and older; use as directed.
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- Relieves severe congestion and pain, including headaches and nasal congestion.
- Trusted cold and cough brand among healthcare professionals.
- Contains Acetaminophen for effective relief of minor aches and pains.
- Includes Guaifenesin to thin and loosen mucus for chest congestion relief.
- Features Phenylephrine HCl to alleviate nasal and sinus congestion and pressure.
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#3
28% Off
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- 24-count Tylenol Sinus Severe Daytime Caplets for non-drowsy relief of cold, hay fever, and respiratory allergies
- Offers pain relief, decongestion, and expectoration for chest and nasal congestion, sinus headaches, and pressure
- Contains 325 mg acetaminophen for pain relief and fever reduction; 5 mg phenylephrine HCl for nasal decongestion; and 200 mg guaifenesin to enhance cough productivity
- Non-drowsy formula promotes sinus drainage and decongests sinus passages, aiding in cough productivity
- Suitable for adults and children aged 12 years and older, from a doctor-recommended brand
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- 24-count Tylenol Sinus Severe Daytime Caplets for non-drowsy relief of cold, hay fever, and respiratory allergies
- Offers pain relief, decongestion, and expectoration for chest and nasal congestion, sinus headaches, and pressure
- Contains 325 mg acetaminophen for pain relief and fever reduction; 5 mg phenylephrine HCl for nasal decongestion; and 200 mg guaifenesin to enhance cough productivity
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#4
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- 24-count Tylenol Sinus + Headache Daytime Caplets provide non-drowsy relief from sinus and headache pain associated with colds and allergies
- Contains acetaminophen for pain relief and phenylephrine HCl as a nasal decongestant to ease nasal congestion
- Each caplet consists of 325 mg of acetaminophen and 5 mg of phenylephrine HCl, targeting sinus headaches and reducing fever
- The formula promotes sinus drainage and alleviates pressure without causing drowsiness, suitable for daytime use
- Recommended for adults and children aged 12 and older, offering effective relief from cold symptoms
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- 24-count Tylenol Sinus + Headache Daytime Caplets provide non-drowsy relief from sinus and headache pain associated with colds and allergies
- Contains acetaminophen for pain relief and phenylephrine HCl as a nasal decongestant to ease nasal congestion
- Each caplet consists of 325 mg of acetaminophen and 5 mg of phenylephrine HCl, targeting sinus headaches and reducing fever
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#5
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- 10 coated tablets for convenient use
- Contains 200mg of ibuprofen for effective relief of fever and body aches
- Includes 10mg of phenylephrine HCl for sinus pressure and congestion relief
- Portable design for on-the-go relief
- Suitable for adults and children ages 12 and up
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- 10 coated tablets for convenient use
- Contains 200mg of ibuprofen for effective relief of fever and body aches
- Includes 10mg of phenylephrine HCl for sinus pressure and congestion relief
- Portable design for on-the-go relief
- Suitable for adults and children ages 12 and up
#6
25% Off
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- Maximum strength gels provide relief for allergies and sinus issues when used as directed.
- Offers fast relief from cold, hay fever, and allergy symptoms.
- Contains a pain reliever, cough suppressant, antihistamine, and nasal decongestant.
- Alleviates sneezing, runny nose, and itchy/watery eyes.
- Includes ingredients for cough suppression and relief from nasal and sinus congestion.
- Eligible for HSA/FSA coverage; verify with your plan.
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- Maximum strength gels provide relief for allergies and sinus issues when used as directed.
- Offers fast relief from cold, hay fever, and allergy symptoms.
- Contains a pain reliever, cough suppressant, antihistamine, and nasal decongestant.
- Alleviates sneezing, runny nose, and itchy/watery eyes.
- Includes ingredients for cough suppression and relief from nasal and sinus congestion.
- Eligible for HSA/FSA coverage; verify with your plan.
#7
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- Provides relief from nasal congestion, sinus pressure, headaches, and pain.
- Effectively treats sinus symptoms due to colds, hay fever, and upper respiratory allergies by reducing sinus pressure.
- Combines decongestant and pain relief for comprehensive sinus symptom management.
- Eligible for HSA and FSA; confirm with your provider for specifics.
- Not an antihistamine; does not address runny nose, itchy/watery eyes, or sneezing.
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- Provides relief from nasal congestion, sinus pressure, headaches, and pain.
- Effectively treats sinus symptoms due to colds, hay fever, and upper respiratory allergies by reducing sinus pressure.
- Combines decongestant and pain relief for comprehensive sinus symptom management.
- Eligible for HSA and FSA; confirm with your provider for specifics.
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#8
11% Off
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- 24-count bottle of Tylenol Cold Head Congestion Severe Caplets for relief of cold and flu symptoms
- Effective relief from headache, sore throat, nasal congestion, and sinus pressure; temporarily reduces fever
- Contains 325 mg of acetaminophen for pain relief and fever reduction, plus 5 mg of phenylephrine HCl for nasal congestion
- Includes 200 mg of guaifenesin to help loosen mucus; does not contain dextromethorphan HBr
- Recommended for adults and children 12 years and older for comprehensive symptom relief
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- 24-count bottle of Tylenol Cold Head Congestion Severe Caplets for relief of cold and flu symptoms
- Effective relief from headache, sore throat, nasal congestion, and sinus pressure; temporarily reduces fever
- Contains 325 mg of acetaminophen for pain relief and fever reduction, plus 5 mg of phenylephrine HCl for nasal congestion
- Includes 200 mg of guaifenesin to help loosen mucus; does not contain dextromethorphan HBr
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#9
23% Off
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- 20 tablets of Sudafed PE Sinus Congestion, formulated for daytime and nighttime relief of sinus pressure and congestion
- 12 daytime tablets containing 10 mg of phenylephrine HCl for effective daytime symptom control
- 8 nighttime tablets with 10 mg of phenylephrine HCl and 25 mg of diphenhydramine HCl to address nighttime symptoms
- Relieves sinus pressure, nasal congestion from colds, hay fever, and upper respiratory allergies; nighttime tablets also treat sneezing and itchy, watery eyes
- Suitable for adults and children 12 years and older, from a pharmacist-recommended brand
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- 20 tablets of Sudafed PE Sinus Congestion, formulated for daytime and nighttime relief of sinus pressure and congestion
- 12 daytime tablets containing 10 mg of phenylephrine HCl for effective daytime symptom control
- 8 nighttime tablets with 10 mg of phenylephrine HCl and 25 mg of diphenhydramine HCl to address nighttime symptoms
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#10
25% Off
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- Maximum strength formula providing fast relief from sinus pressure, congestion, and nasal discomfort.
- Effectively alleviates nasal congestion due to allergies, colds, and hay fever without causing drowsiness.
- Each tablet contains 5 mg of phenylephrine, a decongestant, and 325 mg of acetaminophen for pain and fever relief.
- Suitable for adults and children aged 12 and older; dosage is two tablets every 4 hours, with a maximum of 10 tablets in 24 hours.
- Available in a pack of 24 tablets, recognized as the top recommended OTC decongestant by pharmacists.
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- Maximum strength formula providing fast relief from sinus pressure, congestion, and nasal discomfort.
- Effectively alleviates nasal congestion due to allergies, colds, and hay fever without causing drowsiness.
- Each tablet contains 5 mg of phenylephrine, a decongestant, and 325 mg of acetaminophen for pain and fever relief.
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